Prof. Nils-Göran Larsson

Professor/Senior Consultant

My interest in mitochondrial biology started in 1987 when I began my PhD studies of pathogenic mtDNA mutations causing mitochondrial disease in humans. I decided to get proper training in biochemistry and mouse genetics and went to Stanford University as a HHMI Physician Postdoctoral Fellow in 1994. When I returned to Sweden in 1997, I started my own research group at Karolinska Institutet and developed a series of powerful mouse models. In 2008, I was recruited as one of the founding Directors to the new Max Planck Institute for Biology of Ageing in Cologne, Germany. Between 2008 and 2015, I remained affiliated to KI and kept a small research group here. In 2016, I was recruited back to have KI as my main working place. From 2019, I will be an external member of the Max Planck Society.

Dr. Camilla Koolmeister

Head of Division

Susanne Virding

Biomedical Scientist

Dr. Mara Mennuni

Research Coordinator

I am passionate about science, with a background in studying mitochondrial dysfunction and its role in the onset of diseases. Currently, I focus on coordinating research projects and supporting Larsson team by helping things run smoothly. When I am not working, you will find me playing beach volleyball, tasting delicious food, or exploring the marvels of the world.

Dr. Jelena Misic

Postdoc

Leila Izadi

Research Assistant

Dr. Taolin Yuan

Postdoc

My research is focused on investigating the effect of mitochondrial defects on metabolic rewiring in vivo. A better understanding of the relationship between mitochondrial impairment and metabolic response, can help us gain insights in pathophysiology and development of treatment of diseases associated with mitochondrial dysfunction. Outside of the lab, I like exploring beauty in nature and history. Email: taolin.yuan@ki.se

Dr. Pauline Michon

Postdoc

I graduated with a PhD in cancer research from the University of Bordeaux, France. During this time, I studied metabolic rewiring in skin cancer. I am now a postdoctoral researcher in Larsson group. Other activities that she enjoys are photography, yoga and sports in nature, skiing and scuba diving.

Dr. Polyxeni Papadea

Postdoc

My research is focused on two main aspects. The first one has to do with investigating the mechanisms of maternal transmission of mitochondrial DNA mutations. The recently developed editing techniques give us now the tools to study in depth the maternal transmission of mitochondrial DNA. My second focus is the investigation of the effect of mitochondrial defects on metabolic rewiring in vivo. Targeting mitochondria could give us insights into the mechanisms that cause metabolic disorders and subsequently could also lead to the development of treatments. Outside the lab, I like playing tennis and travelling.

Dr. Kristina Bubb

Postdoc

Dr. Benjamin Munro

Postdoc

My research is focused on understanding how nuclear mutations affect the ability of the cell to replicate mitochondrial DNA (mtDNA), with a particular focus on DNA polymerase gamma, the sole DNA polymerase in mitochondria. Using primarily in vivo models, we aim to recapitulate patient phenotypes so we can better understand the disease pathophysiology and develop potential therapies. Outside of the lab, I spend my time running and enjoying the outdoors. Email: Benjamin.munro@ki.se

Dr. Karolina Borankova

Postdoc

My research investigates the impact of mtDNA mutations on KRAS-driven lung cancer. Using genetic mouse models and single-cell approaches, I aim to explore how mtDNA mutations influence tumor growth and cancer progression. mtDNA mutations are common in cancer, but it remains unclear whether they act as driver or passenger mutations. Hence, my research could provide important insights into cancer pathophysiology and potentially pave the way for novel therapeutic strategies. Outside the lab, I enjoy orienteering and other outdoor activities such as hiking, cycling, and cross-country skiing. e-mail: karolina.borankova@ki.se